Enhancement of Pyruvate Derivative Production in Methanotrophic Bacteria via Integrated Carbon Fixation and CRISPR Base Editing

Development of a Cell-Free Enzymatic Cascade for CO₂-to-Formaldehyde Conversion

Improved Metabolic Flux Estimations through Compositional Data Analysis

Discover the Maze-like Network for Glabridin Biosynthesis

Construction of a multi-copy system with flexible engineering space based on rDNA autonomous regeneration

Functional Characterization of Enone Oxidoreductase Orthologs Highlights Hidden Furaneol Biosynthetic Capacity in Apples

Green Biosynthesis of the Cosmetic Humectant Isoprene Glycol in Escherichia coli via Metabolic Engineering

Metabolic rewiring of oleaginous yeast for efficient production of the aromatic compound tyrosol

Cardamine hupingshanensis: an emerging plant chassis to produce Selenolanthionine and sugar-associated selenium metabolites

Construction of an efficient and universal Yarrowia lipolytica chassis for the biosynthesis of pterocarpans and their derivatives

Solar-driven biosynthesis of chemicals from phosphite-rich wastewater and carbon dioxide

Development of a novel biocatalyst for renewable formaldehyde production

Improving extracellular electron transfer of Zymomonas mobilis to build an industrial electroactive microbial chassis

Variation in the synthesis of specialized metabolites in Erythroxylum coca: A biotechnological approach using callus cultures

Ethylene glycol as a bridge from sustainable carbon to microbial products

Q & A

Ino80-mediated regulation of nitrogen metabolism and targeted epigenome engineering of stress tolerance in Saccharomyces cerevisiae

Metabolic engineering Methylobacterium extorquens AM1 for biosynthesis of 1,4-Butanediol and succinic acid

Multi-step Metabolic Engineering Optimization of Escherichia coli BL21 Star (DE3) for High-efficient Production of Hydroxytyrosol

Synthetic ATP auxotrophy enables control over cellular carbon and electron flow

Metabolic Engineering of Methylorubrum extorquens AM1 for P(3HB-co-4HB) Biosynthesis from Methanol

Engineering a synthetic CH₂-THF carbon-entry module enables formate assimilation through a redesigned metabolic architecture

Genome-Guided Sugarcane Bagasse Bioconversion by Bacillus sp. T2 and Exometabolomic Discovery of Value-Added Product Candidates

Engineering yeast Yarrowia lipolytica for De Novo Biosynthesis of psychedelic compounds

Claim-Level Forensic Reconstruction of Metabolic-Engineering Evidence Chains

AlphaGEM enables precise genome-scale metabolic modelling by integrating protein structure alignment with deep-learning-based dark metabolism mining

Precision engineering of probiotics with prime editing

Improving Mevalonate Yield through a Synthetic Threonine Pathway

Rewiring pyruvate synthesis improves cell growth of Clostridium ljungdahlii during microbial electrosynthesis

An AI-assisted genome-scale metabolic atlas of Y1000+ yeasts reveals dark metabolism, cross-scale diversity and mitochondrial specialization

Q & A