Guidance Talk

Growth-coupled selection drives evolution of Rubisco promiscuity towards formate-based glycolate production

MAP of the Future: Establishing a Next-generation C1 Biofoundry at BRIGHT

Short-chain alcohols fueled orthogonal conversion of pyruvate via a non-natural cofactor

Engineering Schizochytrium as a Next-Generation Cell Factory for Functional Lipid Biosynthesis

Biomanufacturing of Omega Fatty Acids Driven by Synthetic Biology

Microbial Synthesis of 4'-O-methylnorbelladine, the Universal Precursor of Amaryllidaceae alkaloids

Small RNAs Enable Programmable Metabolic Engineering at Conjugated Polymer–Microbe Interfaces

Ancestral reconstruction reveals a flavin-shielding design principle for photostable fatty acid photodecarboxylases

Rational engineering of cytochrome P450 catalysis overcomes biosynthetic bottlenecks for microbial manufacturing of complex natural products

Design of a Novel Diamine Biosensor to Guide the Engineering of Escherichia coli for Cadaverine Overproduction

Multichromatic Dynamic Control of Multi-Membered Microbial Consortia Compositions for Chemical Production

A hybrid system enables plasmid copy number control in yeast

An Efficient Microbial Secretion Platform for Scalable Production of Protein-based Materials from C₂ Feedstocks

Q & A

PCR Leaping Enables High-Throughput Cloning of Biosynthetic Gene Clusters

Low‑pH‑Driven Succinic Acid Biomanufacturing: Chassis Optimization and Metabolic Remodeling of Yarrowia lipolytica

Development of Advanced Gene Expression Tools for Bacillus licheniformis: Engineered Translation Systems and Dynamic Induction Platforms for Microbial Cell Factory Applications

Construction and Optimization of Biosynthetic Pathways for Multiple Organic Acids

Biosystem design of Corynebacterium glutamicum cell factory for producing biochemicals from lignocellulosic biomass

Efficient genome editing for oleaginous yeast Rhodotorula toruloides

ESTEEM Strategy: Revolutionizing Enzymatic Catalysis through the Evolutionary Gateway of Enzyme Tunnels

Model-Driven Dynamic Circuit Design for Quorum-Sensing Activation at High Cell Densities

Establishing Vibrio natriegens as a high-performance host for acetate-based poly-3-hydroxybutyrate production

Iterative dissolved-oxygen control combined with growth–production coordination enables efficient erythritol biosynthesis in Yarrowia lipolytica under high-temperature stress

Development of a Sustainable Process for Manufacturing Aquaculture Feed

Synthetic Biology Platform for Production of Novel Anthracycline Anticancer Agents

Q & A

Enhancement of Pyruvate Derivative Production in Methanotrophic Bacteria via Integrated Carbon Fixation and CRISPR Base Editing

Development of a Cell-Free Enzymatic Cascade for CO₂-to-Formaldehyde Conversion

Improved Metabolic Flux Estimations through Compositional Data Analysis

Discover the Maze-like Network for Glabridin Biosynthesis

Construction of a multi-copy system with flexible engineering space based on rDNA autonomous regeneration

Functional Characterization of Enone Oxidoreductase Orthologs Highlights Hidden Furaneol Biosynthetic Capacity in Apples

Green Biosynthesis of the Cosmetic Humectant Isoprene Glycol in Escherichia coli via Metabolic Engineering

Metabolic rewiring of oleaginous yeast for efficient production of the aromatic compound tyrosol

Cardamine hupingshanensis: an emerging plant chassis to produce Selenolanthionine and sugar-associated selenium metabolites

Construction of an efficient and universal Yarrowia lipolytica chassis for the biosynthesis of pterocarpans and their derivatives

Solar-driven biosynthesis of chemicals from phosphite-rich wastewater and carbon dioxide

Development of a novel biocatalyst for renewable formaldehyde production

Improving extracellular electron transfer of Zymomonas mobilis to build an industrial electroactive microbial chassis

Variation in the synthesis of specialized metabolites in Erythroxylum coca: A biotechnological approach using callus cultures

Ethylene glycol as a bridge from sustainable carbon to microbial products

Q & A

Ino80-mediated regulation of nitrogen metabolism and targeted epigenome engineering of stress tolerance in Saccharomyces cerevisiae

Metabolic engineering Methylobacterium extorquens AM1 for biosynthesis of 1,4-Butanediol and succinic acid

Multi-step Metabolic Engineering Optimization of Escherichia coli BL21 Star (DE3) for High-efficient Production of Hydroxytyrosol

Synthetic ATP auxotrophy enables control over cellular carbon and electron flow

Metabolic Engineering of Methylorubrum extorquens AM1 for P(3HB-co-4HB) Biosynthesis from Methanol

Engineering a synthetic CH₂-THF carbon-entry module enables formate assimilation through a redesigned metabolic architecture

Genome-Guided Sugarcane Bagasse Bioconversion by Bacillus sp. T2 and Exometabolomic Discovery of Value-Added Product Candidates

Engineering yeast Yarrowia lipolytica for De Novo Biosynthesis of psychedelic compounds

Claim-Level Forensic Reconstruction of Metabolic-Engineering Evidence Chains

AlphaGEM enables precise genome-scale metabolic modelling by integrating protein structure alignment with deep-learning-based dark metabolism mining

Precision engineering of probiotics with prime editing

Improving Mevalonate Yield through a Synthetic Threonine Pathway

Rewiring pyruvate synthesis improves cell growth of Clostridium ljungdahlii during microbial electrosynthesis

An AI-assisted genome-scale metabolic atlas of Y1000+ yeasts reveals dark metabolism, cross-scale diversity and mitochondrial specialization

Q & A

DNA Modification by Sulfur： Mechanistic Insight Drive SynBioTec Foward

Accelerating Metabolic Engineering with AI and Robotics

Transforming Food Production for Sustainability: Microbes to Eat CO₂; Humans to Eat Microbes

Biomanufacturing of Aromatic Compounds

Q & A

Engineering Fatty Acid Synthase to Control Chain Length and Its Application in Yeast

Microbial Cell Factories Manufacture Plant Natural Products

Glucose-Driven Evolution of Pseudomonas putida Awakens Catabolism of Lignocellulose-Derived Pentoses

Engineering Microbes for Dynamic Host-Microbiome Modulation

Q & A

Engineered Commensals for Metabolic Modulation of the Gut-Liver-Brain Axis

Expanding the biosynthetic capability of Corynebacterium glutamicum for lutein production

Multi-omics analysis reveals the impact of LincRNA deletion on yeast protein synthesis

Engineering Penicillium rubens as a Next-Generation Fungal Chassis for Flavonoid Biosynthesis

Complementary Yeast Biosensors for Intracellular and Extracellular Lactate

Global analysis of natural product diversity from extreme environments reveals vast untapped biosynthetic potential

Synthesis of aromatic PHAs as sustainable hot-melt adhesives

Rational design of self-assembling protein scaffolds for enzyme performance reconstruction and efficient cascade catalysis

Enhancing PgUGT activity and thermostability via mutation site screening aided by molecular docking structure and computer-aided design for efficient industrial synthesis of Rebaudioside D

Rewiring carbon-nitrogen metabolism and remodeling methyltransferase enables high-level de novo melatonin biosynthesis in yeast

Engineering all human milk oligosaccharide fucosidic linkages in planta

Engineering microbes for a multidimensional circular economy – plastic monomers to OH-fatty acids as an example

Engineering Red Yeast-Based Cell Factories

Synthetic biology and process engineering facilitate the highly efficient production of rhamnolipid

The BRIGHT Biofoundry: Translating Biological Data into Biosolutions — from Pest Control to Human Nutrition and further

An RNA-Tethering Platform for Target-Specific Translation Enhancement

Customizing Micro-Grain for Nutrient Production Through Low-Carbon Microbial Manufacturing

Synthetic Biology-Enabled Lignin Valorization via Artificial Funneling Pathways and Metabolic Engineering

A Cross-Feeding Yarrowia lipolytica-Pseudomonas putida Consortium for Efficient Valorization of Lignocellulosic Oligosaccharides

Biological Upcycling of Methane into Multicarbon Chemicals by Metabolically Engineered Methanotrophs

Bioproduction Valuable Acetyl-CoA Derivatives with Rhodotorula toruloides

Q & A

Engineering Microbial Cell Factories for Precision Biomanufacturing of Chondroitin Sulfate

Bioconversion of Lignocellulosic Biomass to Fuels and Chemicals via DLC Sugar Platform

Synthetic Domestication of Environmental Bacteria for Efficient Biorefineries

Advanced Methanotrophic Cell Factory for Methane-to-Multi-Carbon Bioconversion

Acetoin Bioproduction from H₂ and CO₂ with Methanothermobacter thermautotrophicus

Engineering Yeast Cell Factories for Circular Biomanufacturing from Waste Feedstocks

Harnessing Microbial Metabolic Repertoire for Biological Upcycling of Wastes: Towards Sustainable Development

Engineering Lignin Derived Aromatic Feedstocks for Sustainable Biomanufacturing of High Value Products

Bioconversion for Ursodeoxycholic Acid Using β-Cyclodextrin Included-Chenodeoxycholic Acid via Immobilized Cells of Xanthomonas maltophilia

Mechanism Elucidation of Efficient Organic Acids Production in Industrial Filamentous Fungi

Q & A

Q & A

Discovery and engineering of plant chemistry for plant and human health

Spatiotemporal Control of Metabolism via Engineered Membraneless Organelles

Writing Genomes and Metagenomes, and the Advent of Synthetic Evolution

Synthetic genetic control systems for smart living therapeutics

RNA splicing regulators for gene network and metabolic programming

Engineering SOS-Responsive DNA Damage Circuits for High-Precision CRISPR Genome Editing

Engineering Tailoring Reactions for Efficient Natural Product Biosynthesis

Synthetic yeast communities and cell factories for biosustainability

Open Fermentation Enabled by Enhanced Cellular Robustness: Mining and Design of Stress-Resistance Parts

Accelerating the DBTL Cycle: Echo MS+ Enables Million-Scale Screening in Synthetic Biology

Q & A

Deciphering the Pyrethrins Biosynthetic Pathway and Heterologous Reconstitution in Nicotiana benthamiana

Mapping the Sequence-Function Landscape of Proteins and Biological Systems

Synthetic biology strategies for enhanced production of aromatic polyketides in E. coli

Semi-artificial photosynthesis enables light-driven biomanufacturing in non-photosynthetic bacteria

Production of etoposide and teniposide in yeast to protect endangered plant

Engineer enzymes and cellular metabolism for the synthesis of specialty/unusual fatty acids

Harnessing photoenzymatic reactions for unnatural biosynthesis in microorganisms

Carbon- and Cost-Efficient Upcycling of Agrifood Waste into Fatty Acid Esters by Systematically Engineered Clostridium tyrobutyricum

De novo production of polycyclic polyprenylated acylphloroglucinols in engineered microbes

Q & A

Yarrowia lipolytica as a chassis for synthetic biology: from genome editing to metabolic engineering

Rethinking Fermentation: Freeing Production from Redox Constraints

Engineering Modular Polyketide Synthases via Domain-Domain Interaction Design

Enabling Fluorinated Molecule Biosynthesis: From Biocatalysis to Engineered Streptomyces Cell Factories

Global reprogram of regulation and metabolism for secondary metabolite production

Conversion of syngas-derived C2 carbon sources to C2+ biochemicals by microbial cell factories

Engineering Bacillus methanolicus for methanol-based biomanufacturing of amino acids and single cell proteins

Q & A

Manufacturing Plant Natural Products by Microorganisms

Metabolic engineering of microorganisms toward sustainable biomanufacturing of chemicals and polymers

Regulation and Engineering of Monoterpenoid Indole Alkaloid Biosynthesis

Systematic analysis of signal peptides for engineering protein secretion in yeast

Design and Optimization of Artificial Biological Carbon Fixation Systems

Repurposing Ogataea polymorpha into a superior microbial platform for bio-productions

Q & A

Toward precise kinetic models of acetogen metabolism

AI and systems approach for multiscale optimization in biomanufacturing

AI4S Empowering Biomanufacturing

AI agents for microbial cell factory design

Biosensor-guided genetic circuits for dynamic control of sustainable biomanufacturing

Advancing Cellular Digital Modeling through Artificial Intelligence

M.I.A. — A Deterministic Bioprocess AI AgentJasper

Q & A

Designing Gene Regulatory Programs with AI

Self-driving Bioprocess Digital Twins for Next-Generation Biomanufacturing

The Development of Ultraviolet Laser Dissociation-Structural Mass Spectrometry

AI-driven quantification of tissue metabolic fluxes in vivo

AI-driven digital cell modeling for cell factory design

Rational design of metabolic engineering strategies based on modulating the expression of transcription factors

Q & A

Engineering Microbial Cells and Communities for Sustainable Food Biomanufacturing

Engineering Methanotrophs for Value-added Bioproduct Synthesis from C1 Gases

Modulating gene co-expression and metabolic flux in the yeast Saccharomyces cerevisiae by harnessing the regulatory plasticity of divergent transcription

Beyond Pathway Engineering: Matching Chassis to Feedstocks and Products

Rewiring energy homeostasis in Yarrowia lipolytica enables efficient terpenoid biosynthesis

Developing continuous evolution systems for enhancing microbial protein bioproduction

A Versatile Genetic Toolbox for Metabolic Engineering of Xylose-Utilizing Scheffersomyces stipitis

Biological synthesis of astaxanthin by using yeasts

Engineering Electroactive Microbes: Toward Direct Electricity-Driven Biosynthesis

The Glutathione Metabolic Regulation Is Elucidated in a Novel Marine Aromatic Probiotic Yeast Meyerozyma guilliermondii GXDK6 under Salt Stress

Construction of chassis cell for the efficient production of natural products from myxobacteria

Q & A

Conversion of lignocellulose into bulk chemicals through consolidated bioprocessing using filamentous fungi

Data-driven Engineering Biology for Biomanufacturing: The Power of Accurate and Scalable Data Acquisition

Engineering microbial consortia in time and space

Metabolic engineering-enabled C1 feedstocks upgrading

Developing the marine alga Nannochloropsis as a light-driven eukaryotic chassis for converting CO₂ to value-added products

Tailoring Precise Genomic Integrative Expression Toward Rational Strain Development for Scalable High-titer Production of PHA

Drafting a guidebook on transcription factor-ome in Yarrowia lipolytica, and new studies beyond

Discover and Produce Marine Natural Products Using Genome Mining and Synthetic Biology Tools

Molecular Farming in Tobacco (Nicotiana tabacum): Tissue-Specific and Flux-Redirected Metabolic Engineering of Forskolin

A nonclassical biosynthetic route enables tocopherol synthesis in bacteria

Q & A

Single-Cell Metabolic Engineering (SME) and Single-Cell Process Engineering (SPE) by the Ramanomics Platform

Identification and Biological Effects of Gut Microbial Metabolites and Engineering Microbiology

AI-empowered Function Mining and Synthetic Bioanufacturing for Pharmaceuticals and Nutraceuticals Aiming at Translation

Synthetic Biomanufacturing of Amphiphilic Lipopeptide and Its Cross-disciplinary Applications

Technical progress and industrial scale-up of enzymes for non-food biomass utilization

Fungal Metabolic Engineering for Efficient Biomanufacturing: Mining and Expanding Biodiversity

Modular Engineering Strategies for the Development of Genetically Encoded Biosensors

Q & A

From Proteins to Central Metabolism: Multi-Scale Engineering Redefining Biomanufacturing

Synthetic Biology Empowers the 5M Paradigm for Intelligent BiomanufacturingTM

Orthogonal biomanufacturing using formyl-CoA elongation pathways

Intelligent Multi-Scale Biomanufacturing: Driving Sustainable Isomaltulose Production from Lab to Industrial Scale

An Integrated Synthetic Biology Platform for Sustainable Production of Structural Protein Materials from C2 Feedstocks in Corynebacterium glutamicum

Multiscale Engineering of Terpenoid Biosynthesis in Saccharomyces cerevisiae

Indigenous Pakistani Coal-Mine Fungi for Next-Generation Feedstock Biomanufacturing: A Green Approach to Chemical Production

Q & A

An intramolecular energy metabolism of Streptococcus equisimilis hyaluronan synthase

Catalytic Promiscuity and Protein Engineering of Bacterial CYP152 Peroxygenases for Green Biomanufacturing

Bio-upcycling of plastic waste through enzymatic and biological conversion

Discovery, engineering and application of carbohydrate-active enzymes

Molecular recognition-driven biomanufacturing

Adenylation Domain Engineering Enables Biosynthesis of an Improved Polymyxin Antibiotic

Deracemization by designed photoenzymes

From catalytic-motif scaffolding to de novo sequence-specific proteases: computational pipelines for enzyme design

A Modular Chemoenzymatic Platform for Efficient Synthesis of Aporphine Alkaloids

Metabolic Engineering-Driven Large-Scale Biomanufacturing of Human Milk Oligosaccharides: From Pathway Design to Industrial Applications

Q & A

Computational Design of Functional Enzymes

Engineering enzymes and cascade biotransformations for green and sustainable final chemical synthesis

Novel Enzymatic Transformation Enabled by Redox Driving Forces

Repurposing Thiamine-Dependent Enzymes with Radicals

Decouple Gene Transcription and Translation Regulation in Bacteria

From Nitrogen Fixation to Carbon Valorization: Engineering Nitrogenases for New Chemistry

Title: Artificial Intelligence-Driven Enzyme Sequence Optimization and Its Applications

Metabolic engineering of Escherichia coli for methanol utilization

Engineering a Photodecarboxylase and Enzyme Cascades for Bioproduction of Aromatic Chemicals

Q & A

Developing Biomanufacturing to Support China's Dual-Carbon Goals

Systems Metabolic Engineering of Microorganisms for the Biomanufacturing of Chemicals and Materials

Extremophilic Biomanufacturing

From Marginal Gains to Major Improvements in Yeast Cell Factories

Engineering Mixed Cultures for Gas Fermentation: Converting Biogas into Sustainable Protein

Q & A

Making peptides the non-ribosomal way: possibilities & limitations

Biomanufacturing of future food ingredients: From lab to industry

Q & A